In patients with kidney fibrosis, there is an imbalance between M1 and M2 macrophages. In this situation, M2 macrophages, which normally suppress inflammation, proliferate excessively and secrete ...

This study reveals that neutrophil extracellular traps (NETs) drive macrophage-derived chemokine production (CXCL9/10/11) to promote CD8+ T cell ...

The unique nature of macrophages allows them to change their phenotype from M1 to M2 in response to kidney injury - a process known as polarization.

Lung macrophages play a pivotal role in diseases like idiopathic pulmonary fibrosis. Two types of macrophages—the white blood ...

In patients with kidney fibrosis, there is an imbalance between M1 and M2 macrophages. In this situation, M2 macrophages, which normally suppress inflammation, proliferate excessively and secrete ...

George’s study, "Resident macrophage subpopulations occupy distinct microenvironments in the kidney," was recently published in JCI Insight. The team in George’s lab studies the role of immune cells ...

September 2, 2010 — The combination of fibrosis and inflammation at 1 year is associated with kidney transplant failure, even in recipients with no clinical risk factors for poor outcomes. The ...

Scientists have developed a treatment for pulmonary fibrosis by using nanoparticles coated in mannose -- a type of sugar -- to stop a population of lung cells called macrophages that contribute to ...