Renal fibrosis is the final manifestation of various chronic kidney diseases. Interstitial myofibroblasts, which are reported to highly express integrin αvβ3, are the effector cells in renal ...

This study reveals that neutrophil extracellular traps (NETs) drive macrophage-derived chemokine production (CXCL9/10/11) to promote CD8+ T cell ...

Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of ...

Furthermore, IFN-γ was shown to suppress macrophage IL-10 secretion induced by TLR agonists. NO production was necessary for macrophage tumoricidal activity. We conclude that two signals from the ...

Moreover, M1 macrophages exhibited a propensity for generating high levels of reactive oxygen species (ROS), which subsequently provoked oxidative stress and exacerbated inflammation, thereby ...

Abstract Or112: Indoxyl Sulfate Suppresses GAS6 and Impairs Anti-Atherogenic Macrophage Function: A Novel Mechanism Driving Accelerated Atherosclerosis in Chronic Kidney Disease ...

Their polarization states (M1/M2) directly influence disease progression, while mitochondrial metabolism, as the central hub of cellular energy metabolism, has recently been shown to play a key role ...