This study reveals that neutrophil extracellular traps (NETs) drive macrophage-derived chemokine production (CXCL9/10/11) to promote CD8+ T cell ...

In patients with kidney fibrosis, there is an imbalance between M1 and M2 macrophages. In this situation, M2 macrophages, which normally suppress inflammation, proliferate excessively and secrete ...

In sepsis-induced AKI, Csf2, which is a cytokine secreted by injured TECs, promotes the transition of M1 macrophages to M2 macrophages. Interestingly, certain M2 macrophages that express CD206 and ...

In patients with kidney fibrosis, there is an imbalance between M1 and M2 macrophages. In this situation, M2 macrophages, which normally suppress inflammation, proliferate excessively and secrete ...

September 2, 2010 — The combination of fibrosis and inflammation at 1 year is associated with kidney transplant failure, even in recipients with no clinical risk factors for poor outcomes. The ...

James George, Ph.D. James George, Ph.D., professor in the Division of Cardiothoracic Surgery, is the latest winner of the Heersink School of Medicine’s Featured Discovery. This initiative celebrates ...

During rejection of a transplanted kidney, certain immune cells transform into connective tissue cells, which produce collagen and other fibers. This transition, which is mediated by the TGF ...

Nanoparticle targeting of de novo profibrotic macrophages mitigates lung fibrosis. Proceedings of the National Academy of Sciences, 2022; 119 (15) DOI: 10.1073/pnas.2121098119; ...