Patterning of the nephron along the proximal–distal ... and the developmental defects found in human patients. Induction of the kidney occurs through reciprocal interactions between an ...

These important genetic associations identified in human renal hypoplasia have ... in the MM leading to a 50% decrease in both kidney size and nephron number in adult mice (33).

More information: Toshikazu Araoka et al, Human iPSC–derived nephron progenitor cells treat acute kidney injury and chronic kidney disease in mouse models, Science Translational Medicine (2025).

Each kidney contains over one million microscopic filtering units called nephrons. Each nephron is made of a tubule and is responsible for 'cleaning' the blood by removing urea and excess water ...

A research team led by Kyoto University said Wednesday it has prevented kidney functions from declining in mice using human ...

Using UniMat, the team successfully produced kidney organoids featuring nephron structures and blood vessels similar to those found in human kidneys from human-induced pluripotent stem cells ...

Meanwhile, only about 2,000 patients can receive new kidneys annually due ... more than 100-fold proliferation of nephron progenitor cells derived from human iPS cells compared with conventional ...