Non-competitive antagonists may occlude or block the ion channel, as indicated ... of nAChRs in synaptic signaling in both the neuromuscular junction and sympathetic ganglia, there is a scarcity ...

The nAChRs are ligand-gated ion channels that are present in both the PNS (at the skeletal neuromuscular junction and in the autonomic nervous system) and the CNS. They are integral membrane ...