Instead, Kimura (1968, 1969) proposed that most changes at the molecular level have little functional consequences, or are ‘neutral'. If a mutation has no fitness consequence, its fate in the ...

Most non-neutral mutations are deleterious. In general, the more base pairs that are affected by a mutation, the larger the effect of the mutation, and the larger the mutation's probability of ...

Detrimental mutations, on the other hand, tend to be lost because they are selected against. This disagreement about the frequency of neutral versus advantageous mutations remains unsettled ...

This could alter an individual's phenotype. A mutation can be neutral and have no effect or can have an advantageous or disadvantageous effect on an individual that possesses it. Mutations are the ...