MANILA, Philippines — Bank of the Philippine Islands (BPI) booked a record P62 billion in net profit last year, up by 20 percent, as its loan portfolio expanded. In a stock exchange filing on ...

Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

AYALA-LED Bank of the Philippine Islands (BPI) on Monday said that it posted a record net income of P62 billion last year, up 20 percent from 2023's P51.7 billion and led by strong revenues that were ...

MANILA, Philippines — Profit of Ayala-led Bank of the Philippine Islands (BPI) jumped by 20 percent to hit an all-time high of P62 billion in 2024 from the previous year’s P51.7 billion ...

cGAS can also act as a selective autophagy receptor for micronuclei causing their ultimate degradation and thereby prohibiting them from releasing DNA into the cytosol. Finally, K48-linked ...

Autophagic flux was examined by the buildup of p62 or ubiquitinated organelle protein. Endolysosomal structures were examined by electron microscopy. Cell-specific autophagy was evaluated by ...

This Patent Highlight integrates bifunctional degraders, leveraging autophagy via p62, and substituted oxazolone compounds targeting IKZF1–4 transcription factors. These compounds demonstrate ...

Our findings identify EZRIN as a critical regulator of autophagy via TSC complex in response to EGF stimuli and establish the central role of early endosomal signaling in the regulation of mTORC1.