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Frontiers28d
α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies
Tanji et al. identified autophagosomal proteins, such as LC3, GABARAP, and HDAC6, in LBs, suggesting that they facilitate autophagy and assist in the degradation of aggregated proteins. Autophagic ...
Frontiers1mon
Ultrastructural evidence for the activation of autophagy and analysis of the protective role of autophagy in goat spermatozoa under liquid storage
Notably, a large number of vesicles with double-membrane structure indicating autophagosome were found to surround the aberrant spermatozoa, suggesting the activation of autophagy. Several proteins, ...
C&EN1mon
Crystal Structure of Autophagy-Associated Protein 8 at 1.36 Å Resolution and Its Inhibitory Interactions with Indole Analogs
State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China ...
eLife8y
Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons
Autophagy defects have been linked to Alzheimer’s disease (AD). However, the mechanisms underlying altered autophagy remain unknown. Here, we demonstrate that defective retrograde transport ...