A precision medicine workflow integrating proteomics and personalized xenograft models was developed and applied to an adolescent with progressive SETTLE tumor. Target identification combined with pre ...

1 Unlike patient-derived tumor xenografts, 3D models eliminate cross-species incompatibilities and offer greater control over experimental conditions. Compared to 2D cultures, where cells proliferate ...

Preclinical studies have demonstrated IDE275's (GSK959) potential as a best-in-class WRN inhibitor, inducing single-agent tumor regressions in MSI-H patient-derived xenograft (PDX) and cell line ...

LaunXP receives exclusive development and commercialization rights for vebreltinib in combination with an EGFR inhibitor in Asia (excluding ...

ZW171, a mesothelin (MSLN)-targeting T cell engager, currently in global Phase 1 clinical studies, shows promising preclinical activity in an expanded range of MSLN-positive tumor models including ...

The scientists tested zotatifin against prostate tumor biopsies that were transplanted into mice. This type of experiment, called a patient-derived xenograft, is considered a gold standard for showing ...

Researchers explore how natural compounds in traditional Chinese medicine can modulate cholesterol metabolism to combat cancer.

Researchers have uncovered a promising therapeutic target for adenoid cystic carcinoma (ACC), a rare cancer of the salivary glands with few treatment options. The study, "PRMT5 inhibition has a ...

However, these treatments are associated with limited long-term efficacy in certain patient ... xenograft tumors in a dose-dependent manner. Celastrol also upregulates ABCA1 expression in tumor ...