“The assumption is that what grows out in the PDX is reflective of the bulk of the tumor in the patient,” study author and cancer geneticist Todd Golub, of both the Broad Institute, at MIT, and ...

Dobrolecki LE, Lewis MT. Surgical Procedure for Implantation of Human Tumor Tissue into the Epithelium-Free Mammary Fat Pad of Immunocompromised Mice to Generate Patient-Derived Xenografts (PDX).

Participants expressed that they would sacrifice an unlimited number of mice for their child, yet only 63% endorsed a willingness to use up to 1,000 mice per patient. Willingness to use more mice ...

This study is led by Prof. Kenneth To (School of Pharmacy, The Chinese University of Hong Kong) and Dr. William Cho ...

1 Unlike patient-derived tumor xenografts, 3D models eliminate cross-species incompatibilities and offer greater control over experimental conditions. Compared to 2D cultures, where cells proliferate ...

These patient-derived xenografts (PDX or “xenolines”) are representatives of the patient’s tumor but with the advantage that they are testable model systems. We are evaluating ways to use high content ...

Preclinical studies have demonstrated IDE275's (GSK959) potential as a best-in-class WRN inhibitor, inducing single-agent tumor regressions in MSI-H patient-derived xenograft (PDX) and cell line ...

To achieve their research goals, the lab employs a variety of experimental approaches, including in vivo models such as orthotopic xenograft models and patient-derived xenografts ... pSTAT3 ...