In a first step toward FDA approval of kidney xenotransplantation, a living human with end-stage kidney disease may receive a ...

Porcine Possibilities Courtesy of PPL TherapeuticsA new generation of pigs. Headlines in late summer 2000 introduced long-awaited reports on pig cloning and retroviral transmission to mice, pig cells ...

The world's first recipient of a gene-edited pig kidney died from cardiac causes within 2 months, but there was no evidence of xenograft rejection, a brief report detailed. After undergoing the ...

Porcine collagen products such as Enduragen (Endur), Matriderm (Matri), and unspecific porcine collagen products had been used for defects of 0.4 to 27.3 cm 2. IDRT and IDRT-SL had a healing time of 8 ...

Abstract 4146311: Cardiac Thickening, Cell Free DNA, and Rejection in the 2 nd Porcine Cardiac Xenograft Andrew Tully, MD, Muhammad Mohiuddin, MBBS, Javier Galindo, MD, Sarah Cipriano, CRNP, Kapil ...

The patient required ECMO support POD31 and chose comfort care POD 40. Research Questions/Hypothesis: The cardiac xenograft doubled in mass from implant to autopsy. Donor derived cell free DNA (cfDNA) ...

Background— Glutaraldehyde fixation (G-F) decreases but likely does not eliminate the antigenicity of bioprosthetic heart valves. Rejection (with secondary dystrophic calcification) may be why G-F ...

The Maryland researchers also detected traces of a latent pig virus, called porcine cytomegalovirus, or PCMV, in Bennett’s blood. The virus can cause inflammation and cell damage.

Both of the deceased’s kidneys were removed and replaced with one genetically modified pig kidney, which was screened for any potential pathogens like porcine cytomegalovirus. The new kidney ...

The pig was positive for PCMV/PRV DNA, and the authors also detected PCMV/PRV DNA in the transplanted xenograft; however, no tissue from the patient had an actively transcribing virus.