A serotype-specific mAb-based NS1 antigen-capture ELISA has recently been developed and shows good serotype specificity. This test can differentiate between primary and secondary dengue virus ...

More information: Huaqi Tang et al, Revealing Mechanopathology Induced by Dengue NS1 Using Organ Chips and Single-Cell Force Spectroscopy, ACS Biomaterials Science & Engineering (2025).

The major diagnostic markers for dengue infection include detection of the dengue virus, viral RNA, and viral antigens such as the NS1 protein ... is a primary or a secondary infection.