Mitosis orchestrates eukaryotic cell division, maintaining genetic fidelity and playing a key role in development, tissue homeostasis, and cancer progression.

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

The spindle-assembly checkpoint contributes to APC-substrate ordering by delaying the ubiquitination of some substrates until chromosomes are properly attached to the mitotic spindle. APC ...