As it advances, excessive fibrosis or buildup of scar tissue impairs the ability of the kidneys to filter toxins from the blood and reabsorb water, often leading to kidney failure. There are ...

The study, published in Science Translational Medicine, highlights the role of type 5 collagen - a minor component of scar tissue - in kidney fibrosis, and shows how an experimental therapy could ...

Currently, the company’s portfolio includes PAT-1251, a phase 2-ready LOXL2 inhibitor for the treatment of idiopathic pulmonary, liver and kidney fibrosis, and PAT-409, a phase 1-ready ATX ...

The study, published in Science Translational Medicine, highlights the role of type 5 collagen — a minor component of scar tissue — in kidney fibrosis, and shows how an experimental therapy ...

The study, published in Science Translational Medicine, highlights the role of type 5 collagen — a minor component of scar tissue — in kidney fibrosis, and shows how an experimental therapy could help ...

reduced signs of kidney injury in these mice. Overexpression of PPDPF improved mitochondrial activity, increased NAD + levels, enhanced NMNAT activity, and reduced markers of fibrosis and injury ...

“These findings strongly support targeting PPDPF as a potential therapy for kidney fibrosis, offering possibilities for future CKD interventions,” the authors wrote. This work was supported by ...

People living with cystic fibrosis can now take a once-daily drug that will help them breathe easier all day long, thanks to ...

We further demonstrated that a low-protein diet activated AMPK independent of the AMP sensing mechanism, leading to improvement in energy metabolism and kidney fibrosis.