Scientists have imaged the toxic clumps and fibres made by expanded huntingtin with cutting-edge microscopes, helping us to understand the exact way they can be assembled and how their structure could ...

In Huntington’s disease research, biomarkers are the secret weapon for spotting treatment effects. A new blood study uncovers two proteins, CAP1 and CAPZB, that, with additional work, could help track ...

The gut and brain are connected by a busy two-way superhighway. In Huntington’s disease, traffic on this road may be jammed, detoured, or carrying harmful cargo, linking gut microbes, inflammation, ...

Some childhood experiences stay with us, quietly shaping how we feel as adults. For those raised in families with Huntington’s disease, this new study helps make sense of those feelings, and reminds ...

While the genetic change that causes Huntington’s disease (HD) leads to several problems for cells, researchers believe they could stem from one core issue: the length of the genetic change increasing ...

Sleep is more than a nightly recharge, it is fundamental to brain health. A landmark 12-year study tracking people with the gene for Huntington’s disease (HD) suggests how specific sleep disturbances ...

team of researchers from Roche and University College London (UCL) have developed a new clinical measure called the Huntington’s Disease Digital Motor Score (HDDMS). This score compiles data collected ...

Huntington’s disease doesn’t just damage the brain, it also breaks down muscles and fat, and disrupts nutrition early on. New work suggests there’s a hidden physical decline in early HD, so monitoring ...

New research maps Huntington’s disease progression like a symphony unraveling. The brain first overcommunicates, then loses sync, and finally falls silent, each stage driven by different biological ...

New research is challenging how we think about treating brain diseases, like Huntington’s disease (HD). A study from the lab of Dr. Steven Goldman shows that transplanting healthy early-stage support ...

We learned on July 25, 2025 that Prilenia’s application to the European Medicines Agency’s (EMA) for pridopidine was not accepted for marketing authorization. While this is perhaps not surprising ...

When the Brain’s Clock Breaks: Sleep Disruption and Circadian Chaos in Huntington’s Disease July 28, 2025 ...