Conversely, proteins associated with “cell cycle” and “p53 pathway,” including SFN, showed a persistent increase starting at 3 h and peaking at 48 h. Western blotting and immunohistochemistry ...

5Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, ...

Icaritin (ICA) is a prenylflavonoid natural product extracted from plants of the Epimedium genus. The approval of ICA softgel capsules as a class 1.2 traditional Chinese medicine (TCM) innovative drug ...

Interestingly, the Sirt1-p53 axis has dual action acting both as a tumor suppressor ... human glioblastoma (U-87MG), lung cancer (A549), and triple negative breast cancer (MDA-MB-231) cell lines have ...

The key tumor suppressor protein p53, additionally known as p53, represents an attractive target for the development and management of anti-cancer therapies. p53 has been implicated as a tumor ...

An inadequate supply of amino acids leads to accumulation of uncharged tRNAs, which can bind and activate GCN2 kinase to reduce translation. Here, we show that glutamine-specific tRNAs selectively ...