Cold' tumors are resistant to common immunotherapies. Researchers have uncovered a master regulator that can be manipulated to prevent tumor growth in mice.

An “inverse vaccine” that delivers deactivated allergens to the liver was able to reduce reactions in mice with allergic asthma for at least a year after treatment. Should the approach ...

such as the dorsal root ganglia or the liver, which may help avoid toxicities commonly associated with AAV delivery. Using TRACER, Voyager is also identifying capsids with the capacity for strong ...

Removing EPO signaling in mouse liver tumors leads to tumor regression along with sensitivity to immunotherapy.

AAV4 also mostly avoids the liver, a major target ... gene therapy studies in mice more efficient and reproducible, given that a lot of the homework on the best AAV for a given cell type has ...

Deverman and Eid realized that datasets based on existing large AAV libraries weren't ... and the ability to target the liver across human cells and mice. Almost 90 percent of these proteins ...

Blocking the activity of the protein turns formerly “cold,” or immune-resistant, liver tumors in mice into “hot” tumors teeming with cancer-fighting immune cells. When combined with an ...