EU agencies unite to tackle azole fungicide resistance in Aspergillus fungi: Amsterdam, The Netherlands Monday, February 3, 2025, 17:00 Hrs [IST] For the first time, t ...

Second, there is a greater chance of drug interactions. Azole antifungals (e.g., fluconazole, itraconazole and voriconazole) alter metabolism of cyclophosphamide, a cytotoxic agent, through ...

Treatment for athlete’s foot may involve topical antifungal ointments, available to purchase over-the-counter (OTC) or online. Severe infections may require additional oral medications.

"These findings illuminate a critical mechanism that connects local synaptic activity to the broader gene expression changes necessary for learning and memory," said Mark Dell'Acqua, professor of ...

School of Science, Asymmetric Synthesis and Chirotechnology Key Laboratory of Sichuan Province, Xihua University, Chengdu 610039, P. R. China ...

The international team describes their results and the underlying molecular mechanism in Cell Metabolism. Ergothioneine is a natural compound found in certain fungi such as oyster or shiitake ...

Agrichemical use of antifungals has created moulds with a propensity to ... reduced the effectiveness of azoles. ‘Azole-resistant isolates are five times more likely to gain resistance to the new drug ...

Opelconazole is a potent novel investigational azole therapy specifically designed for inhaled ... of adding to the toxicities and drug-drug interactions seen with systemic antifungal therapies.

Pulmocide's investigational product, opelconazole, is currently in a Phase 3 clinical trial (NCT05238116) in patients with Invasive Pulmonary Aspergillosis (IPA) who are not responding to antifungal .

The findings, reported in Nature Communications, also solve a decades-long scientific puzzle that’s prevented drugmakers from successfully using azole antifungal drugs to treat visceral ...