In the first comprehensive, cell-by-cell analysis of brain tissue from individuals with Tourette syndrome, researchers have ...

Mar. 25, 2025 — A drug typically prescribed for arthritis halts brain-damaging seizures in mice that have a condition like epilepsy, according to researchers. If the ... New Rules for the Game ...

The pattern of binding to these residues differs in basal and desensitized conformations, further supporting the notion that these sites modulate the allosteric transitions of the nAChR.

Apr. 3, 2025 — Parkinson's doesn't just affect movement and the brain -- it may also impact the heart, according to new research. Scientists suggest that targeting a key protein outside of the ...

To this end, we combined a dynamic model of dopamine with a neurocomputational model of the basal ganglia with multiple action channels. We also included a dynamic model of tonic and phasic dopamine ...

The rewarding effects of drugs of abuse, development of incentive salience, and development of drug-seeking habits in the binge/intoxication stage involve changes in dopamine and opioid peptides in ...