From the Department of Medicine, University of Chicago. Supported in part by a grant (AM-07091) from the United States Public Health Service. † Assistant professor of medicine, Department of ...

The metabolism of bilirubin begins with its production from heme in the spleen and bone marrow, followed by transportation to the liver, where it undergoes enzymatic conversion. The liver plays a ...

Conjugation of bilirubin and delivery to the intestine doesn't necessarily lead to excretion of the substance. Neonatal intestines contain beta-glucuronidase, an enzyme capable of reducing ...