Adding to his sins, He knew after the gene editing — but before the embryos were transferred to their mother’s uterus — that one of the twins, whom he called Lulu, had a normal CCR5 allele ...

Nature is complicated, viruses are tricky, assumptions are dangerous — and He Jiankui's CRISPR experiment on human embryos was, amazingly, even worse than I first thought.

Recent studies have shown higher frequencies of the CCR5-Δ32 allele and the CCR5-Δ32/Δ32 genotype, which confers protection against HIV infection, in northern Europe as compared to ...

Recent epidemiological data and projections indicate that HIV infection will spread rapidly in India. An allele Δccr5 of the β-chemokine receptor gene CCR5 has been found to confer protection ...

Individuals homozygous for the CCR5 gene Δ32 allele appear to naturally resist infection with CCR5-tropic HIV strains (R5) because they lack cell surface expression of CCR5. Stem Cell Transplant ...

To the Editor: In 2009, my colleagues and I reported the successful transplantation of stem cells with a 32-bp deletion in the chemokine (C-C motif) receptor 5 (CCR5) allele (CCR5 delta32/delta32) ...

In addition to chemotherapy, he underwent a haematopoietic stem cell transplant from a donor with two copies of the CCR5 Δ32 allele in 2016. CCR5 is the most commonly used receptor by HIV-1.

The identified CCR5 allele carries a deletion (delta 32) that seems to inactivate the receptor. As chemokines signal through their receptors and influence T-cell migration, a defect in one of the ...

In 1996, researchers discovered that CCR5 encodes a receptor on CD4+ cells that HIV uses to enter the cells early on during an infection. People who have two copies of the so-called Δ32 allele don’t ...

It turned out that this patient had one naturally mutated CCR5 allele. “Since half the subject’s CCR5 genes were naturally disrupted, the gene editing approach was building on the head start ...

A second person has experienced sustained remission from HIV-1 after ceasing treatment, according to a study published today in Nature. The case report, carried out by researchers at UCL and Imperial ...

Homozygosity for a 32-bp deletion in the CCR5 allele (CCR5 delta32) prevents cellular entry of CCR5-tropic (R5-tropic) HIV type 1 (HIV-1) strains. In 2009, ...