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Two more people have been potentially cured of HIV after receiving stem cell transplants to treat blood cancer or bone marrow disease, physicians reported Monday.
Specifically, the patient received a CCR5 wild-type, delta 32 transplant, known as a heterozygous transplant, for acute myeloid leukemia, investigators reported at the International AIDS ...
In addition to the donor's CCR5-delta-32 status, the type of conditioning therapy prior to the transplant, the severity of graft-versus-host disease, the size of the pre-existing viral reservoir, and ...
CCR5 is a receptor protein on white blood cells that HIV uses to infect cells; with the delta-32 mutation, the virus can’t bind to the protein and enter the cell. As a retrovirus, HIV then ...
Unlike Brown and most of the others, the newest case involved a transplant from a heterozygous donor — someone with only one copy of the mutation, called CCR5-delta 32, which prevents HIV from ...
The patient received an HCT from a donor with the rare delta-32 mutation, which causes a CCR5 deletion (CCR5-Δ32/Δ32) and has been associated with resistance to HIV-1 infection, Jana Dickter, MD ...
The mutation is called "homozygous CCR5 delta 32," it makes those with it immune to most kinds of HIV. It's currently estimated that only 2% of people in the world have this rare mutation.
They knew of other cases when transplants of this sort — using stem cell donations from people with a specific genetic mutation that means they lack what is called the "CCR5-Delta 32 receptor ...
When the patient was diagnosed with biphenotypic sarcoma in 2018, he underwent chemoradiation therapy and then had an allogeneic stem cell transplant from a donor who had wild-type CCR5, he said.
This case suggests that using stem cells with the CCR5-delta-32 mutation may not be necessary to achieve long-term HIV remission. If so, this would make it easier to find suitable donors for ...