Proliferation index is an important prognostic factor in breast cancer. The Ki-67 protein is expressed in all phases of the cell cycle except G0 and serves as a good marker for proliferation. Studies ...

Histone methylation (H3K36me3 barrier) by NSD2 promotes the functions of genes involved in cell proliferation. NSD2 decreases in senescent cells, which causes altered epigenome and gene expression ...

In prior research, each gene needed a different viral vector ... which facilitate faster cell division. Those cells that went through this hyper-proliferation phase became considerably easier ...

The research shows that novel cancer drugs designed to inhibit CDK7 can, within minutes, shut down gene expression pathways that drive cell proliferation in dozens of different kinds of tissues.

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.