Cysts, fibrosis, and tubular degeneration form the typical triad of pathologies leading to the gradual decline in kidney ...

New research led by Unity Health Toronto that examines how fibroblast cells in the body are activated to cause fibrosis and organ scarring has been published in Nature Reviews Molecular Cell Biology.

New research has revealed that removing a protein called gasdermin D can protect the liver from inflammation and scarring in alcohol-induced acute-on-chronic liver failure (ACLF). But this comes at a ...

The differential diagnoses for CRCC include RCC with cystic change, hereditary leiomyomatosis manifesting as a cystic renal lesion, cystic nephroma, clear cell papillary RCC, and other cystic ...

Research led by Children's Hospital of Fudan University in China has found that a gene called pancreatic progenitor cell differentiation and proliferation factor (PPDPF) helps protect kidney cells by ...

Researchers have identified type 5 collagen as a key factor in kidney fibrosis, revealing its potential as a biomarker to predict chronic kidney disease progression. A repurposed anti-cancer drug, ...

Moreover, the cells and soluble factors participating in this response in liver are also similar to those in parenchymal injury to kidney, lung, or skin. Fibrosis occurs earliest in regions where ...

New UCLA research conducted using mouse models and human genetic data has uncovered a critical factor that determines how much scarring occurs following kidney injury, leading scientists to identify a ...

This activates αvβ3 integrins — receptors in fibroblast cells that sense the weakened tissue and respond by producing even more scar tissue. This cycle of excessive fibrosis leads to worsening kidney ...

Research led by Children's Hospital of Fudan University in China has found that a gene called pancreatic progenitor cell differentiation ... markers of fibrosis and injury in renal tissue.