Mitochondrial diseases, arising from mutations in mitochondrial DNA (mtDNA), are a diverse group of disorders that lead to ...

Here, we discover lysophospholipids as endogenous pannexin activators, using activity-guided fractionation of mouse tissue extracts combined with untargeted metabolomics and electrophysiology. We show ...

The same biological processes that drive aging — such as energy loss — may also contribute to lung diseases like chronic ...

Scientists at Johns Hopkins Medicine say they have discovered how a group of proteins linked to Parkinson's disease and amyotrophic lateral sclerosis act as "guardians" of mitochondria, small ...

Apr. 4, 2025 — New research shows how small shifts in the molecular makeup of a virus can profoundly alter its fate. These shifts could turn a deadly pathogen into ...

How do tennis world rankings work? Tennis world rankings are calculated by the ATP and WTA, who award points based on a player's performance at particular tournaments. The further a player ...

How do tennis rankings work? Tennis world rankings are calculated by the ATP, who award points based on a player's performance at particular tournaments. The further a player progresses in a ...

Stem cells can be unipotent, multipotent, pluripotent or totipotent, depending on the number of cell types to which they can give rise. We show that multipotent neural stem cells (NSCs ...

Senescence is the process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence can be induced by unrepaired DNA damage ...

2017). WalK is represented by a cartoon tube model, the His391 is represented by balls-sticks model, and AMPPCP (a nonhydrolyzable analog of ATP) is represented by sticks model, in which oxygen atoms ...