Researchers discovered a previously unknown mechanism that may drive tissue damage and a new target for drug discovery.

Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system—a group of proteins that ...

“Our findings provide new insights into how chronic inflammation might be triggered and sustained in autoimmune and inflammatory diseases,” said senior author Michael B. Brenner, MD.

Background Early-life inflammation has long been recognised as a key pathophysiological process in the evolution of cystic ...

Mitochondria, often seen as cellular powerhouses, play a surprising role in immune regulation. Researchers found that ...

This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...

Researchers found that compared with patients with no comorbid chronic inflammatory diseases, those with comorbid atopic dermatitis, bronchial asthma, or Hashimoto thyroiditis were significantly more ...

The Capsule Endoscopy Crohn's Disease Activity Index (CECDAI) was designed to evaluate the severity of inflammation, disease extent and small bowel strictures. [16] In the validation process ...

Other times, the inflammatory process lasts longer than it needs to. This "bad" type of inflammation, called chronic inflammation, is associated with long-term pain or health conditions. Containing an ...