A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

I hypothesized that mechanisms of DNA repair may create a circle of viral DNA that is more resistant to [degradation],” Lai said. To test this idea, Lai and his colleagues treated HIV infected cells ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, ...

introduces double-strand breaks that recruit DNA repair machinery. Despite its successes, the CRISPR-Cas9 system has several limitations, including off-target cutting. Over the years, scientists have ...

Then, Crispr runs a seek-and-destroy function. After that, other molecules are dispatched to repair the gene with new, healthy DNA. And just like that, you can edit the human genome. But while ...

Once a cut is made, it is a multistep, imperfect process of cellular DNA repair. CRISPR can be used to make other types of edits too, such as increasing or decreasing the effects of a gene ...

that can repair any damage caused by CRISPR-Cas systems. Defense systems that the bacteria uses to protect itself from foreign DNA often co-localize within defense islands (genomic segments that ...

Genome editing with various CRISPR-Cas molecule complexes ... The latter requires a copyable template for repair to accurately rejoin the DNA at the cut site. The slow variant is called homology ...

Using CRISPR technology, scientists uncovered genes that control C-A-G genetic stumbles in Huntington's disease ...

Base editors fuse enzymes that can alter the chemical structure of DNA bases to a “dead” version of CRISPR/Cas9 that doesn ... Inter-homologue repair in fertilized human eggs?

The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell. After that, the next step in CRISPR gene editing is usually to alter that piece of DNA. However ...