Multi-dimensional single cell RNAseq data projected as 2D UMAP plots. Top: clusters colored to represent tissue of origin: normal adjacent tissue (blue) or tumor endothelial cells (red) in ...

Endothelial cells -- the cells that line blood vessels -- grown alongside leukemia cells become corrupted and rescue the cancer cells from many chemotherapy drugs, a study found.

The team also validated tumor tissue samples from 226 patients across 10 solid cancer types by single-cell RNA sequencing analysis and found that the EndoMT pathway results in the formation of ...

Circulating tumor cells (CTCs) and endothelial cells (CECs) in the diagnosis of malignant pleural mesothelioma (MPM): A single-institutional prospective study.. JCO 28 , e18024-e18024 (2010). DOI: ...

In an animal model of the aggressive brain tumor glioblastoma, they saw malignant pericytes from human tumors wrap around endothelial cells, as they would to form blood vessels, but they also ...

Preventing metastasis – the development of cancer cells beyond their original location – remains one of the major goals of current cancer research. Most malignant tumor cells metastasize by ...

Paraffin-embedded tissue sections from 10 MYCN-amplified tumors (six stage 4, three stage 3, and one stage 1) were studied.Endothelial cells (ECs) were detected by immunofluorescent staining for CD31 ...

Other investigational therapies for malignant gliomas include chemotherapeutic agents that cross the blood−tumor barrier more effectively, gene therapy, 105 peptide and dendritic-cell vaccines ...

In APL Bioengineering, researchers examine the local communication between endothelial cells and tumors cells and its effects on endothelial cell orientation. The approach uses co-cultured human ...

Evolution of tumor cells (green) within a normal organoid (gray). The lower panel shows surface rendition of tumor cells and labels new cells that arise from a single cell in the same color.