Which of the statements about the use of tumor necrosis factor inhibitors for managing rheumatic disorders are correct?

Background Liver metastasis is a major cause of mortality in patients with colorectal cancer (CRC). Understanding how CRC cells influence the formation of hepatic premetastatic niches (PMNs) is ...

Cellular aging may explain persistent liver stiffness after HCV eradication, with shorter telomeres linked to poorer hepatic ...

The portal tracts, which include branches of the hepatic artery, portal vein, and interlobular bile duct within a fibrous matrix, are assessed for the presence of chronic inflammation and for ...

Background: While tumour necrosis factor α (TNF-α) appears to be associated with the development of non-alcoholic steatohepatitis (NASH), its precise role in the pathogenesis of NASH is not well ...

Whenever extreme hyperglobulinemia has been described in liver disease, it has been associated with subacute hepatic necrosis or postnecrotic cirrhosis, on a presumed infectious or toxic basis. 19 ...

Stimuli driving stellate cell activation include hepatocellular necrosis due to oxidant stress, apoptosis, and soluble growth factors. Specific lymphocyte subsets can also stimulate fibrogenesis.

The work reported here aims to use a multimodal imaging approach to investigate whether the toxicological findings of the multifocal hepatocellular necrosis and bile duct hyperplasia, along with ...

Systemic administration of recombinant ADAMTS13 decreased hepatic platelet accumulation, downregulated VWF expression, and mitigated mouse hepatic necrosis. Conclusions ...

In the early stages of hepatocellular carcinoma (HCC), doctors may recommend surgical removal, a liver transplant, or ablation. Learn more about treating HCC here.

The findings of this study suggest that macrophage-based immunotherapy approaches targeting hepatic necrosis could be a promising new treatment strategy for various liver diseases.