Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by motor dysfunction (parkinsonism) and several non-motor features. Dysautonomia is a significant non-motor feature ...

Management Adjustment of dopaminergic therapy (carbidopa–levodopa and entacapone) to minimize motor fluctuations and camptocormia.

Oral anticoagulants (OACs) are medications commonly used in patients with atrial fibrillation and other cardiovascular conditions. Both warfarin and direct oral anticoagulants are susceptible to ...

A study of entacapone administered with carbidopa/levodopa CR showed less robust enhancement of levodopa AUC, probably due to the more rapid absorption and elimination of entacapone compared with ...

In clinical trials evaluating the addition of entacapone to levodopa/DDCI in patients with motor fluctuations, an increase in dyskinesias and nausea were the most common side effects in entacapone ...

In recent years, large-scale structure-based virtual screening has attracted increasing levels of interest for identification of novel compounds corresponding to potential drug targets. It is critical ...