This study reveals that neutrophil extracellular traps (NETs) drive macrophage-derived chemokine production (CXCL9/10/11) to promote CD8+ T cell ...

Mechanistically, the release of exosomes carrying miR-1306-5p by the HR group promoted more M2 macrophage. Conclusion: ATF3 might accelerate the ferroptosis by inhibiting Nrf2/ARE pathway, and ...

This study unveiled the role of Lrrk2 gene in regulating macrophage polarization and immune response. This finding provides significant insights into the role of Lrrk2 in M1 macrophage modulation ...

To test the role of complement 3a receptor (C3aR1) on macrophages and liver resident macrophages in MASLD, we generated mice deficient in C3aR1 on all macrophages (C3aR1-MjKO) or specifically in liver ...

Researchers at National Jewish Health and colleagues have completed the first study comparing lung macrophages in multiple models of lung injury. The research indicates that macrophages previously ...

In light of the recent findings, researchers in the Arthur lab will evaluate if the presence of HIF-1α+ macrophages could be used to screen future Crohn's disease patient biopsies for fibrosis.

The engineered macrophages were well tolerated and outperformed non-engineered cells in all models. Based on the promising findings, the company is committed to advancing its liver fibrosis program.

Unraveling the role of macrophages in regulating inflammatory lipids during acute kidney injury Date: September 27, 2024 Source: University of Tsukuba Summary: Lipid mediators (LMs), which are ...

The annual number of publications on macrophages and pulmonary fibrosis jumped during 2017 and 2020, with signs pointing to more focus on research in these fields.

Scientists have long known that white blood cells called macrophages accumulate in the lungs of people suffering from pulmonary fibrosis. What role macrophages play in developing the often-fatal lung ...