Cysts, fibrosis, and tubular degeneration form the typical triad of pathologies leading to the gradual decline in kidney ...

Researchers have identified type 5 collagen as a key factor in kidney fibrosis, revealing its potential as a biomarker to predict chronic kidney disease progression. A repurposed anti-cancer drug, ...

A series of experiments in mouse models confirmed these findings: mice with low Col5a1 developed more severe fibrosis and ...

The three key functions of the Core are listed below: These CF mouse models produce no functional Cftr mRNA or protein, and are particularly useful to stufy consequences of the electrophysiological ...

Kidney samples were collected from both mouse models and previously published human datasets ... and reduced markers of fibrosis and injury in renal tissue. According to the authors, the findings ...

fibrosis, and cellular death and degeneration. Its role in PKD had never been examined before. Tsiokas speculated that by genetically deleting Fbxw7 in a mouse model used to study kidney function ...

A comprehensive proteomic map of liver fibrosis progression and healing in two mouse models identifies etiology-specific extracellular matrix components, laying the foundation for targeted ...

Scientists are exploring targeted drugs to prevent cyst formation and improve kidney ... fibrosis, and cellular degeneration in PKD. By deleting this gene in a mouse model, researchers were ...

Repirinast is the Company’s lead candidate for the treatment of CKD based on data showing it reduced fibrosis by 51% with statistical significance and showed an additive benefit to telmisartan in a ...