All had suspected non-perforated appendicitis based on clinical exam, with or without radiological diagnosis. At 12-month follow-up, primary outcome data were available for 846 (90%) patients.

Key takeaways: Preoperative antibiotic treatment did not reduce the risk for appendix perforation in patients with uncomplicated appendicitis. One dose of antibiotics at anesthesia induction ...

Send comments and news tips to [email protected]. Cite this: Antibiotics Pre-Appendectomy Don’t Lower Perforation Risk, But Reduce Infections - Medscape - June 10, 2025.

For certain patients with uncomplicated appendicitis (inflammation without perforation or abscess), antibiotic therapy alone has emerged as a potential alternative to immediate surgery.

Simple appendicitis occurs when a person has an inflamed appendix without the presence of necrosis or perforation. Necrosis is the irreversible injury of cells, which leads to cell death.

Because appendicitis is more difficult to diagnose in children than adults — especially in children younger than 5 — some 30 percent of kids with the condition will suffer from a perforated ...

Medically reviewed by Qin Rao, MD A perforated bowel, or intestinal perforation, occurs when a hole forms in the wall of the ...

In a five-year follow-up, nearly two-thirds of patients never needed surgery. After more than a century of slicing tiny, inflamed organs from people's guts, doctors have found that surgery may not be ...

Appendicitis can feel very similar to gas. However, unlike gas, appendicitis pain occurs specifically to the lower right of the belly button, is severe, and worsens over the next few hours.

“Early appendicitis is easy to treat; late and perforated appendicitis usually has a longer hospital stay and can have weeks of treatment until it resolves completely.” ...