Gene therapy addresses genetic disorders by correcting defective genes, but delivery remains challenging. Viral vectors, while efficient, pose risks ...

A phase 2 trial reveals that combining intratumoral BO-112 with pembrolizumab shows potential in treating anti–PD-1-resistant melanoma.

Patients with anti–PD-1–resistant melanoma (MEL) have no well-defined standard of care. BO-112 is a synthetic, double-stranded RNA (poly I:C) nanoplexed with polyethylenimine that when administered ...

Scale formation is a critical challenge in the oil and gas industry, causing operational inefficiencies and escalating costs. Nanoparticle-based scale inhibitors have emerged as promising alternatives ...

imageimageNeural stem cell (NSC) function in mammalian brains declines during aging, but the molecular mechanisms involved remain ill-defined. Here, integrated multi-omics reveals continuous ...

Adsorbed layers of polyediylenoxide-polypropylenoxide (PEO-PPO) blockcopolymers were tested as neurophobic background coatings in neuronal patterning studies over a time period of 30 days.

The influence of neuron-adhesive pattern geometry on long-term survival of cortical neural tissue (rat brain) was studied over a time period of 15 days. Microwells (depth 0.5 /spl mu/m) with diameters ...

The acrylonitrile and sodium methallyl sulfonate membrane used during extracorporeal blood purification can adsorb cytokines and the polyethylenimine surface can bind endotoxin, Dr Perez-Fernandez’s ...