The kidney is a central organ of the mammalian ... promoting differentiation into proximal tubules. Finally, The most proximal part develops into glomeruli under the control of genes such as ...

The distal portions of the nephron, including the distal convoluted tubule (DCT), the connecting tubule (CNT ... and the analysis of the consequences of kidney-specific gene knockouts on the distal ...

Although the gene has been studied in other physiological and pathological contexts, its role in kidney disease had not been experimentally tested. In the study, "PPDPF preserves integrity of proximal ...

characterized by impaired reabsorption of cystine and dibasic amino acids in the renal proximal tubules. It exhibits a sex-dependent response, with males experiencing an earlier onset of stone ...

Moreover, the mRNA expression levels in the 1+cp and 2+cp groups were significantly lower than those seen in the 10uM Celastrol or Cisplatin 50uM the transcriptional expression of KIM-1, a specific ...

The oncogenic mechanisms by which TFE3 fusion proteins drive translocation renal cell carcinoma (tRCC ... engaging distal and proximal M/E-box-containing regulatory elements, as well as promiscuously ...

Researchers at University of Tsukuba have found that the phosphate concentration in proximal tubule fluid, estimated from urine and blood tests, is associated with elevated renal tubular damage ...

However, the effect and mechanism of ISL on cisplatin-induced renal proximal tubular cell injury remain unknown. In this study, mouse proximal tubular cells (mPTCs) and human proximal tubule ...