Here we studied the role of Fms-like tyrosine kinase 3 ligand (Flt3L) signalling in the pathogenesis of collagen-induced arthritis (CIA). Methods CIA was induced in mice lacking Flt3L (Flt3L −/−) and ...

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

New Jersey hardcore band Gel has broken up mid-tour following what they described as “heinous acts” committed by former guitarist Anthony Webster. In a statement shared across their since-deactivated ...

Tyrosine kinase inhibitors (TKIs ... that targets multiple CDKs, tropomyosin receptor kinases, and Src family kinases, which are involved in cancer cell growth and malignant progression. Janus kinase ...

BM remains a major issue in oncology. Patients with metastases to the CNS have a poor prognosis and current chemotherapy treatments provide responses in only 15–30% of patients, with the median ...

New Jersey hardcore band Gel has announced their breakup, citing allegations against former guitarist Anthony Webster. In a public statement, the band accused Webster of financial misconduct ...

Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1 ... Equal amounts of proteins were loaded into the wells of an SDS-PAGE gel, followed by electrophoresis. The proteins were transferred to a ...

To this end, recent clinical and preclinical studies have implicated the epidermal growth factor receptor signaling pathway in chronic pain states. EGFR is one of four members of the ErbB family of ...