Trained immunity in alveolar macrophages can lead to damaging lung inflammation, confirming the importance of context in this phenomenon.

The immune system can work in two ways: the innate immune system reacts to any foreign invaders that are identified by immune cells that look for such pathogens; but the acquired or adaptive immune ...

The body’s innate immune system senses damage signals, like heat shock proteins (HSP70), and sounds the alarm, mobilizing dendritic cells to fan the flames of inflammation.

Her work focuses on improving vaccine technology to elicit strong immune responses in disease, specifically tuberculosis. Basdeo also investigates the innate immune system and how it responds to ...

However, recent research has challenged this belief, showing that the innate immune system can be trained. This emerging principle, known as trained innate immunity, enables the innate immune system ...

How does the immune system respond to a pathogen? The immune system has two main arms: innate and adaptive. The innate immune system recognizes broad molecular patterns, such as molecules that certain ...

Now, researchers from Penn’s School of Dental Medicine and international collaborators have investigated the effects of training the innate immune system in experimental models of two chronic ...

Researchers at the University of Pennsylvania and international collaborators have shown that innate immune training, also known as trained immunity (TRIM), leads to aggravated bone loss in ...

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By studying the innate immune system, scientists have found connections between the immune systems of bacteria and those of humans. “We only started sequencing large numbers of genomes about 20 years ...

The novel coronavirus SARS-CoV-2 has an enzyme that can counteract a cell’s innate defense mechanism against viruses, explaining why it is more infectious than the previous SARS and MERS ...

Meyer and her team continue to dissect the complicated lives of immune system agents such as innate-like T cells. The findings pave the way for future research and may help to advance immunotherapies.