The role of centrosomal tubulin glutamylation has remained elusive for decades. Here, a new tool enables precise ...

This could include studies focusing on different parts of the mitotic spindle, i.e. spindle microtubules, centrosomes and kinetochores, and various key proteins playing important roles in the ...

segregated with the help of the mitotic spindle, and packaged in to daughter cell nuclei. Mitosis occurs in five stages: prophase, prometaphase, metaphase, anaphase and telophase. Stamatov et al.

Mechanistic studies reveal that HDAC6 overexpression disrupts mitotic spindle orientation and positioning in corneal epithelial cells. Our data further show that HDAC6 deacetylates enkurin ...

The membrane-bound aggregates were then cleared as cells progressed through mitosis and cytokinesis. Aggregate clearance was depended on Hsp70 family chaperones in the ER, particularly BiP, and ...

The immune system plays an important role to prevent local growth and dissemination of cancer. Therapies based on activating the immune system can result in beneficial responses in patients with ...

RBM14 is an RNA-binding protein that regulates spindle integrity in mitosis; however, its functions during meiosis are still unclear. In this study, we discovered that RBM14 expression was ...

Simultaneous electroencephalography and functional magnetic resonance imaging (EEG–fMRI) studies have revealed brain activations time-locked to spindles. Yet, the functional significance of these ...

Cells have several ways to prevent aneuploidy. One of these safeguards, known as the spindle assembly checkpoint (SAC), involves a protein called BubR1, which acts at the stage when the duplicated ...