HDAC6 is upregulated in corneal diseases and causes ENKD1 deacetylation at lysine 98. Deacetylation of ENKD1 blocks its ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

Same as in mitosis, except that the spindle fibers from each centriole attach to one chromosome of a matching chromosome pair. In other words, the fibers from one centriole attach to 23 ...

Mitosis is a process of nuclear division in eukaryotic cells that occurs when a parent cell divides to produce two identical daughter cells. During cell division, mitosis refers specifically to ...

Without centromeres, cells cannot divide properly and the overall process of mitosis fails. Why are these small chromosomal regions so essential to such a major cellular process? With a few ...

During mitosis spindles attach a special structure of chromosome, which is called "centromere." In this study, we clarified how centromeres are formed on chromosomes.

A hallmark of tumor cells is an inability to control their proliferation, which implies that these cells are capable of bypassing cell cycle checkpoints and regulation by tumor suppressor signaling ...

In organisms like yeast, spindle pole bodies (SPBs) function similarly but lack centrioles. The SPBs, embedded in the nuclear membrane, orchestrate spindle dynamics during the closed mitosis ...

E.R. Steuer, L. Wordeman, T.A. Schroer, M.P. Sheetz, "Localization of cytoplasmic dynein to mitotic spindles and kinetochores," Nature, 345:266-68, 1990. Michael ...

More information: Cecilia Aquino-Perez et al, FAM110A promotes mitotic spindle formation by linking microtubules with actin cytoskeleton, Proceedings of the National Academy of Sciences (2024).

Each replicated chromosome is made up of two identical strands called chromatids that are joined together. Each chromatid is a full length DNA molecule. The stages outlined in the following ...

Chromosomes begin to condense, taking on the form that they are usually depicted in: four arms connected at a point. Each chromosome is, at this time, actually two identical copies. Each copy is ...