Our laboratory studies both stem cell-intrinsic and extrinsic mechanisms altering tissue renewal capacity, and how such mechanisms ultimately result in the functional decline we recognize as aging.

"With aging, neural stem cells don't respond the way they used to when they were young," says Rebecca Kuntz Willits, Northeastern professor of chemical and bioengineering. "There's fewer of them ...

As we age, blood stem cells, the essential source of new blood cells in the body, can accumulate genetic mutations.

"Immune cell changes occur during aging for a number of reasons ... and a member of the university's Sanford Stem Cell Institute. Crews' lab, in collaboration with researchers at UC Irvine ...

Along with signs of intrinsic, chronological aging, like fine wrinkles and thinning, skin also displays effects of 'extrinsic aging ... (leading to wrinkling), stem cell survival, and loss ...

Stem cells are the only cells in your body that can grow into over 200 different kinds of unique cells. If you have a stem cell transplant, diseased or damaged stem cells in your body are replaced ...

He explained that the skin is the largest organ and undergoes both chronological and extrinsic ... of skin aging such as ...

However, as we age, capacity of stem cells declines, and the resulting drop in tissue repair manifests as the functional decline associated with aging. Our goal is to understand why stem cell activity ...