With changes coming to the rotation and bullpen, Sean Newcomb, Brennan Bernardino, and Josh Winckowski struggled against Seattle.

Triston Casas hit a three-run home run late, but it wasn’t enough as the Red Sox lost Wednesday to the Seattle Mariners.

Miller was able to button that inning up quickly, but labored after that, giving up the go-ahead run in the third when the Red Sox again led off with a base hit, as Cedanne Rafaela singled and then stole second—Boston’s second stolen base of the game already—and then came home on a double from ancient enemy Alex Bregman.