The Los Angeles Chargers began the 2025 NFL draft by selecting North Carolina running back Omarion Hampton with the No. 22 pick in the first round on Thursday night, following up with their first pick on Friday to select Ole Miss wideout Tre Harris in the second round.

The Chargers selected former Clemson safety R.J. Mickens with the No. 214 overall pick in the 2025 NFL draft. Los Angeles added depth to the safety room and a special teams presence with the selection of Mickens in Round 6.

After securing a running back and wide receiver over the first two rounds of the 2025 NFL draft, the Los Angeles Chargers finally addressed the defense with Oregon defensive lineman Jamaree Caldwell at No.