The heart is an omnivore, consuming fuel constantly and using any substrate available. 8 The high rates of ATP production and turnover are critical in maintaining cardiac contractility to deliver ...

Cardiovascular disease is the leading contributor to years lost due to disability or premature death among adults. Current efforts focus on risk prediction and risk factor mitigation‚ which have been ...

WORLD OF EVS EVs are 30- to 1000-nm-sized membranous structures released by cells into the extracellular space (Figure 1). Their membrane, composed of a complex lipid and protein repertoire, ...

BACKGROUND: Upper extremity (UE) motor function impairment is a major poststroke complication whose recovery remains one of the most challenging tasks in neurological rehabilitation. This study ...

Since 1980, the American College of Cardiology (ACC) and American Heart Association (AHA) have translated scientific evidence into clinical practice guidelines (guidelines) with recommendations to ...

Supplementation with omega‐3 (n‐3) fatty acid or dietary fish may protect against atherosclerosis, but the potential mechanisms are unclear. Prior studies found modest triglyceride‐lowering effects ...

The present study used RPT, congenic strains, haplotype analysis, sequencing, and gene expression to establish a small number of genetic variants associated with increased susceptibility of the S rat ...

Provoked anger is associated with an increased risk of cardiovascular disease events. The underlying mechanism linking provoked anger as well as other core negative emotions including anxiety and ...

T he global prevalence of heart failure (HF) is estimated at >30 million individuals. Rapidly increasing in incidence and prevalence, HF is thought to have contributed to 1 in 8 deaths in 2017. 1, 2 ...

Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity and mortality. There have been significant management advances over the past 2 decades, but the burden ...

Methods and Results— In a population-based cohort of older US adults, we evaluated cross-sectional associations of usual dietary fish and ω-3 consumption during the prior year and ECG-derived (n=4263) ...

Rationale:The function of Nox4, a source of vascular H2O2, is unknown. Other Nox proteins were identified as mediators of endothelial dysfunction. Objective:We determined the function of Nox4 in ...